אחד מסוגי התרופות המשמשות לטיפול במחלות פסיכוטיות.

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Noun
1. tranquilizer used to treat psychotic conditions when a calming effect is desired
(synonym) major tranquilizer, major tranquillizer, major tranquilliser, antipsychotic drug, antipsychotic agent, antipsychotic, neuroleptic drug, neuroleptic agent
(hypernym) tranquilizer, tranquillizer, tranquilliser, antianxiety agent, ataractic drug, ataractic agent, ataractic
(hyponym) chlorpromazine, Thorazine

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It occurs in 0.2% of patients on neuroleptic drugs, particularly potent dopaminergic antagonists such as heloperidol.
Symptoms appear a few days to a few weeks after initiation of therapy and consist of:
*hyperthermia
*muscle rigidity
*autonomic instability (tachycardia, labile BP, pallor)
*fluctuating level of consciousness.
Investigations show:
*increased creatinine phosphokinase
*increase WCC
*abnormal liver biochemistry.
Treatment can be:
(a) Specific
bromocriptin--to enhance dopaminergic accuracy
dantrolene--to reduce muscle tone
(b) Nonspecific
general management including temperature reduction.

neuroleptic

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NEUROLETTICO