zymogen – מילון אנגלי-אנגלי
zymogen
n.
substance which converts into an enzyme under certain conditions (Biology)
Zymogen
A
zymogen (), also called a
proenzyme (), is an inactive
precursor of an
enzyme. A zymogen requires a
biochemical change (such as a
hydrolysis reaction revealing the active site, or changing the configuration to reveal the active site) for it to become an active enzyme. The biochemical change usually occurs in
Golgi bodies, where a specific part of the precursor enzyme is cleaved in order to activate it. The inactivating piece which is cleaved off can be a
peptide unit, or can be independently folding domains comprising more than 100
residues. Although they limit the enzyme's ability, these n-terminal extensions of the enzyme or a “prosegment” often aid in the stabilizing and
folding of the enzyme they inhibit.
zymogen
Noun
1. any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active
(synonym) proenzyme
(hypernym) organic compound
Zymogen (das)
n.
zymogen, substance which converts into an enzyme under certain conditions (Biology)
Zymogen
(n.)
A mother substance, or antecedent, of an enzyme or chemical ferment; -- applied to such substances as, not being themselves actual ferments, may by internal changes give rise to a ferment.
Webster's Revised Unabridged Dictionary (1913), edited by Noah Porter.
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