Pacifico or Pacífico may refer to:

• Pacífico, a Mexican pilsner beer originally brewed in Mazatlán, Sinaloa.
• The Pacific Ocean, the largest ocean in the world
• Pacifico, a song by Ugly Casanova from their album Sharpen Your Teeth
• Pacificus of Verona, 9th century archdeacon of Verona
• Pacificus (Pacifico), 13th-century follower of St. Francis of Assisi
• Pacificus of San Severino, 17th-century saint
• Pacifico (band), an American rock band from Georgia, signed to ALLALOM Music
• Pacifico (singer), an Italian singer-songwriter, composer and musician
• Pacifico, an album by The Lassie Foundation
• Pacifico Yokohama, a convention center in Japan.
• Club Deportivo Pacífico FC, a Peruvian football club.
• Pacífico F.C., a defunct Colombian football club.

Cerveza Pacífico Clara, better known as Pacífico, was founded by the Najera family is a Mexican pilsner-style beer. It was first brewed in 1900 when three Germans opened a brewery, the Cerveceria del Pacífico in Mazatlán. Cerveza Pacífico is named so because the Pacífico brewery is located in the Pacific Ocean port city of Mazatlán, in the state of Sinaloa, México. Its label includes a picture depicting a lifesaver encompassing a hill with the port's lighthouse hill, known locally as "Cerro del Crestón." In Mazatlán, the beer is available in four different size bottles: "cuartitos" (6 fl. oz), "medias" (12 fl. oz.), "ballenas" (32 fl. oz.) and "Ballenón" (1.2 L).