Haptens are small molecules that
elicit an immune response only when attached to a large carrier such as a
protein; the carrier may be one that also does not elicit an immune response by itself. (In general, only large molecules, infectious agents, or insoluble foreign matter can elicit an
immune response in the body.) Once the body has generated
antibodies to a hapten-carrier
adduct, the small-molecule hapten may also be able to bind to the antibody, but it will usually not initiate an immune response; usually only the hapten-carrier adduct can do this. Sometimes the small-molecule hapten can even block immune response to the hapten-carrier adduct by preventing the adduct from binding to the antibody, a process called
hapten inhibition.