Daphne (; , meaning "laurel") is a minor figure in Greek mythology known as a naiad—a type of female nymph associated with fountains, wells, springs, streams, brooks and other bodies of freshwater. There are several versions of the myth, but the general narrative is that because of her beauty, Daphne attracted the attention and ardor of the god Apollo (Phoebus). Apollo pursued her and just before being overtaken, Daphne pleaded to her father, the rivergod Ladon, and Ge (Gaia) for help. So Ladon then transformed Daphne into a laurel tree. In Metamorphoses by Roman poet Ovid, she is identified as the daughter of the rivergod Pineios in Thessaly. At the Pythian Games which were held every four years in Delphi in honour of Apollo, a wreath of laurel gathered from the Vale of Tempe in Thessaly was given as a prize. According to Pausanias the reason for this "simply and solely because the prevailing tradition has it that Apollo fell in love with the daughter of Ladon (Daphne)".

DAFNE or DAFNE (Double Annular F Factory for Nice Experiments), is an electron-positron collider at the INFN Frascati National Laboratory in Frascati, Italy. Since 1999 it has been colliding electrons and positrons at a center of mass energy of 1.02 GeV to create phi mesons (f). 85% of these decay into kaons (K), whose physics is the subject of most of the experiments at DAFNE.

Dafne is the earliest known work that, by modern standards, could be considered an opera. The libretto by Ottavio Rinuccini survives complete; the mostly-lost music was completed by Jacopo Peri, but at least two of the six surviving fragments are by Jacopo Corsi. Dafne was first performed during Carnival of 1598 (1597 old style) at the Palazzo Corsi.

Daphne may refer to:

• The nymph Daphne in Greek mythology
• Daphne (opera), an opera by Richard Strauss based on the myth and legend of the beautiful nymph Daphne
• Daphne (plant), a genus of shrubs in the plant family Thymelaeaceae, noted for their scented flowers and poisonous berries