Salicin is an alcoholic ß-
glucoside. Salicin is an
anti-inflammatory agent that is produced in (and named after)
willow (
Salix) bark. Salicin is also commonly found in the bark of
Populus species, and the leaves of willows and poplars. It is also found in
castoreum, which was used as an
analgesic,
anti-inflammatory, and
antipyretic. The activity of castoreum has been credited to the accumulation of salicin from willow trees in the beaver's diet, which is transformed to
salicylic acid and has an action very similar to aspirin. Salicin is closely related in chemical make-up to
aspirin. When consumed, the
acetalic ether bridge is broken down. The two parts of the molecule,
glucose and
salicyl alcohol, then are metabolized separately. By oxidizing the alcohol function the aromatic part finally is metabolized to
salicylic acid. Salicin elicits bitterness like
quinine, when consumed.
Alkaline cleavage of the glucoside
populin produces
benzoate and salicin.