Roche is French for "boulder/rock". The word is (part of) several names:

• Hoffmann-La Roche AG, Basel, Switzerland, one of the largest pharmaceutical companies in the world.
• Roche Applied Science, a business area of Roche Diagnostics, a division of Hoffmann–La Roche AG, Basel, Switzerland, one of the largest pharmaceutical companies in the world.

Ruché (pronounced in English , ) is a red Italian wine grape variety from the Piedmont region. It is largely used in making Ruché di Castagnole Monferrato, a small production red varietal wine which was granted Denominazione di Origine Controllata (DOC) status by presidential decree on October 22, 1987, and was granted the more prestigious Denominazione di Origine Controllata e Garantita (DOCG) status in 2010. The current DOC recognized area of production for the wine, covers only about 100 acres (40 hectares) of vines around the villages of Castagnole Monferrato, Refrancore, Grana, Montemagno, Viarigi, Scurzolengo and Portacomaro. Ruché di Castagnole Monferrato is, therefore, one of the lowest production varietal wines in Italy. The grape is also grown to some extent in the neighboring province of Alessandria.