PIKO (pronounced "peek-oh") is one of the largest and best-known model train brands in Europe and exports to the United States and other parts of the world.

Piko may refer to:

• PIKO, a model train manufacturer
• Street name for Methamphetamine in many Central and Eastern European countries
• Piko (singer), a Japanese pop singer
• Piko (Filipino game), a Filipino children's game similar to hopscotch
• Piko, renamed Penny in English dubbing, a character from the anime Stitch!
• Piko (wrestler), a Japanese professional wrestler