Murrain is an antiquated term for various infectious diseases affecting cattle and sheep. It literally means "death" and was used in medieval times to represent just that. Murrain did not refer to a specific disease, but was an umbrella term for what are now recognized as a number of different diseases, including rinderpest, erysipelas, foot-and-mouth disease, anthrax, and streptococcus infections. Some of these could also affect humans. The term murrain also referred to an epidemic of such a disease. There were major sheep and cattle murrains in Europe during the 14th century, which, combined with the Little Ice Age, resulted in the Great Famine of 1315-1317, weakening the population of Europe before the onset of the Black Death in 1348.