Microcirculation is the
circulation of the
blood in the smallest
blood vessels, present in the vasculature embedded within
organ tissues. This contrasts with
macrocirculation, which is the circulation of blood to and from the organs. The microcirculation is composed of terminal
arterioles,
capillaries, and
venules that drain capillary blood. The vessels on the arterial side of the microcirculation are called the arterioles, which are well innervated, are surrounded by
smooth muscle cells, and are 10-100
µm in diameter. Arterioles carry the blood to the capillaries, which are not innervated, have no smooth muscle, and are about 5-8 µm in diameter. Blood flows out of the capillaries into the venules, which have little smooth muscle and are 10-200 µm. The blood flows from the venules into the
veins. In addition to these blood vessels, the microcirculation also includes
lymphatic capillaries and collecting ducts. The main functions of the microcirculation are the delivery of
oxygen and nutrients and the removal of
carbon dioxide (CO
2). It also serves to regulate blood flow and tissue perfusion thereby affecting blood pressure and responses to
inflammation which can include
edema (swelling).