Mesoglea, also known as mesohyl, is the translucent, non-living, jelly-like substance found between the two epithelial cell layers in the bodies of cnidarians and sponges. Mesoglea refers more correctly to the tissue found in jellyfish and it functions as a hydro-static skeleton. Mesohyl generally refers to tissue found in sponges.

Mesoglea, also known as mesohyl, is the translucent, non-living, jelly-like substance found between the two epithelial cell layers in the bodies of cnidarians and sponges. Mesoglea refers more correctly to the tissue found in jellyfish and it functions as a hydro-static skeleton. Mesohyl generally refers to tissue found in sponges.