Mandel is a surname that occurs in multiple cultures and languages. It is a Dutch, German and Jewish surname, meaning "almond", from the Middle High German and Middle Dutch mandel. Mandel can be a locational surname, from places called Mandel, such as Mandel, Germany. Mandel may also be a Dutch surname, from the Middle Dutch mandele, meaning a number of sheaves of harvested wheat. The name may refer to:

• Alon Mandel (born 1988), Israeli swimmer
• Babaloo Mandel (born 1949), American screenwriter
• David Mandel (born 1970), American television producer and writer
• Eli Mandel (1922–1992), Canadian writer
• Emily St. John Mandel (born 1979), Canadian novelist
• Emmanuil Mandel (born 1925), Russian poet
• Ernest Mandel (1923–1995), Belgian writer
• Georges Mandel (1885–1944), French politician
• Harvey Mandel (born 1945), American guitarist
• Howie Mandel (born 1955), Canadian actor and comedian
• Jan Mandel (born 1956), American mathematician
• Jean Mandel (1911–1974), German footballer and politician
• Johnny Mandel (born 1925), American musician
• Josh Mandel (born 1977), American politician
• Leonard Mandel (1927–2001), American physicist
• Loring Mandel (born 1928), American playwright
• Maria Mandel (1912–1948), Austrian Nazi official
• Marvin Mandel (1920–2015) American politician
• Morton Mandel (born 1921), American businessman
• Robert Mandel (born 1945), American film producer
• Rolfe D. Mandel (born 1952), American archaeologist
• Sammy Mandel (1904–1967), American boxer
• Semyon Mandel (1907–1974), Russian theatre and film designer
• Stephen Mandel (born 1945), Canadian politician
• Stephen Mandel (hedge fund manager) (born 1956), American businessman
• Stewart Mandel (born 1976), American sportswriter
• Suzy Mandel (born 1953), British actress
• Tom Mandel (futurist) (1946–1995), American futurist
• Tom Mandel (poet) (born 1942), American poet
• William Mandel (born 1917), American journalist