KULE may refer to:

• KULE (AM), a radio station (730 AM) licensed to serve Ephrata, Washington, United States
• KZUS, a radio station (92.3 FM) licensed to serve Ephrata, Washington, which held the call sign KULE-FM from 1990 to 2013
• KTRB, a radio station (860 AM) licensed to serve San Francisco, California, United States, which formerly held the call sign KULE

Kule is a village in Ghanzi District of Botswana. It is located close to the border with Namibia and has a primary school, clinic, customary court, social and development offices, animal health and production and police offices. The population was 741 in 2001 census.