Karyogamy is the final step in the process of fusing together two
haploid eukaryotic cells, and refers specifically to the fusion of the two
nuclei. Before karyogamy, each haploid cell has one complete copy of the organism's
genome. In order for karyogamy to occur, the
cell membrane and
cytoplasm of each cell must fuse with the other in a process known as
plasmogamy. Once within the joined cell membrane, the nuclei are referred to as
pronuclei. Once the cell membranes, cytoplasm, and pronuclei fuse together, the resulting single cell is
diploid, containing two copies of the genome. This diploid cell, called a
zygote or
zygospore can then enter
meiosis (a process of chromosome duplication, recombination, and division, to produce four new haploid cells), or continue to divide by
mitosis. Mammalian fertilization uses a comparable process to combine haploid sperm and egg cells (
gametes) to create a diploid fertilized egg.