A gale is a very strong wind. There are conflicting definitions of how strong a wind must be to be considered a gale. The U.S. National Weather Service defines a gale as 34–47 knots (, or ) of sustained surface winds. Forecasters typically issue gale warnings when winds of this strength are expected.

The enzyme UDP-glucose 4-epimerase , also known as UDP-galactose 4-epimerase or GALE, is a homodimeric epimerase found in bacterial, fungal, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose. GALE tightly binds nicotinamide adenine dinucleotide (NAD+), a co-factor required for catalytic activity.