Deoxyadenosine is a
deoxyribonucleoside. It is a
derivative of the
nucleoside adenosine, differing from the latter by the replacement of a
hydroxyl group (-OH) by hydrogen (-H) at the
2' position of its
ribose sugar
moiety. Deoxyadenosine is the DNA nucleoside A, which pairs with
deoxythymidine (T) in double-stranded DNA. In absence of
adenosine deaminase (ADA) it accumulates in T lymphocytes and kills these cells resulting in a genetic disorder known as adenosine deaminase severe combined immunodeficiency disease (ADA-SCID).
