Coagulation (also known as
clotting) is the process by which
blood changes from a liquid to a gel, forming a
clot. It potentially results in
hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion, and aggregation of
platelets along with deposition and maturation of
fibrin. Disorders of coagulation are disease states which can result in bleeding (
hemorrhage or
bruising) or obstructive clotting (
thrombosis).