Aire may refer to:

• Aire (Yuri album), 1987
• Aire, an album by José Mercé
• Aire (Pablo Ruiz album)
• "Aire", a song on Ya Viene el Sol, an album by Spanish group Mecano
• "Aire", a song by Intocable
• "Prelude to Aire" and "Aire", are both instrumental pieces by Chicago, on the album Chicago VII

Aïre is a small locality in the Canton of Geneva. It is on the North bank of the river Rhone. It is near the Lignon, a huge 1 km long block of flats.

The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. AIRE is a transcription factor expressed in the medulla of the thymus and controls the mechanism that prevents the immune system from attacking the body itself.