Tetrahydrocannabinol (
THC), or more precisely its main isomer
(−)-trans-Δ9-tetrahydrocannabinol ((6aR,10aR)-delta-9-tetrahydrocannabinol), is the principal
psychoactive constituent (or
cannabinoid) of
cannabis. First isolated in 1964 by Israeli scientists Prof.
Raphael Mechoulam and Dr. Yechiel Gaoni at the
Weizmann Institute of Science it is a water-clear glassy solid when cold, which becomes
viscous and sticky if warmed. A
pharmaceutical formulation of (−)-
trans-Δ
9-tetrahydrocannabinol, known by its
INN dronabinol, is available by prescription in the U.S. and Canada under the brand name
Marinol. An
aromatic terpenoid, THC has a very low solubility in water, but good solubility in most organic
solvents, specifically
lipids and
alcohols. THC,
CBD,
CBN,
CBC,
CBG and about 80 other molecules make up the
phytocannabinoid family.