Santana may refer to:

• Carlos Santana, Mexican American rock musician and guitarist, founder of the band Santana
  • Santana (band), the band accompanying Carlos Santana
  • Santana (1969 album), the debut album of the above band
  • Santana III, the third album of the above band
• Juelz Santana, an American rapper and member of The Diplomats
• Johan Santana, a Venezuelan baseball pitcher, currently with the Baltimore Orioles
• Jorge Santana, Mexican rock musician and guitarist, brother of Carlos Santana
• Lizette Santana, also known as Lizé, an American recording artist, singer, songwriter, musician, record producer and actress

Sântana (; ; ) is a town in north-western Romania, in the county of Arad. It had 12,936 inhabitants as of 2002. The town is situated in the northern part of the Aradului Plateau, at a 29 km distance from the county capital (Arad). Declared a town in 2003, it administers one village, Caporal Alexa (Erdoskerek).