RPD may refer to:

• Raccoon Police Department, from the Resident Evil video games
• Rack phase difference, an oilfield term
• Raleigh Police Department (North Carolina), police department of Raleigh, North Carolina
• Reactive plasma deposition, a thin film deposition method
• Recognition primed decision, a decision-making model
• Regional policy dialogue, an initiative of the Inter-American Development Bank
• Relative percent difference, a statistical measure of deviation between two measurements
• Removable partial denture, a dental prosthesis for the partially edentulous patient
• Riverside police department, in Riverside, California.
• RNase PH domain, an exoribonuclease domain in certain enzymes
• Robot programming by demonstration, a technique to teach new skills to robots
• Robust parameter design
• Ruchnoy Pulemyot Degtyaryova, a Soviet-made light machine gun

The RPD (Russian: ручной пулемёт Дегтярёва Ruchnoy Pulemyot Degtyaryova, English: Degtyaryov hand-held machine gun) is a 7.62mm light machine gun developed in the Soviet Union by Vasily Degtyaryov for the intermediate 7.62×39mm M43 cartridge. It was created as a replacement for the DP machine gun chambered for the 7.62×54mmR round. It is a precursor of most squad automatic weapons. It was succeeded in Soviet service by the RPK.