Portobelo is a port city and corregimiento in Portobelo District, Colón Province, Panama with a population of 4,559 as of 2010. It is the seat of Portobelo District. It was established during the Spanish colonial period. Located on the northern part of the Isthmus of Panama, it has a deep natural harbor and was used as a center for silver exporting before the mid-eighteenth century and destruction in the War of Jenkins' Ear.

Portobelo is a port city and corregimiento in Portobelo District, Colón Province, Panama with a population of 4,559 as of 2010. It is the seat of Portobelo District. It was established during the Spanish colonial period. Located on the northern part of the Isthmus of Panama, it has a deep natural harbor and was used as a center for silver exporting before the mid-eighteenth century and destruction in the War of Jenkins' Ear.