The Medžitlija-Níki border crossing linking the Republic of Macedonia with Greece is one of the three transit points for road vehicles between the two states. Situated about 190 km from Thessaloniki and the same to Skopje, it also once served as Yugoslavia's southernmost exit. It is located on the European route E65.

The Medžitlija-Níki border crossing linking the Republic of Macedonia with Greece is one of the three transit points for road vehicles between the two states. Situated about 190 km from Thessaloniki and the same to Skopje, it also once served as Yugoslavia's southernmost exit. It is located on the European route E65.