Mannheim ( , Palatine German: Monnem or Mannem) is a city in the southwestern part of Germany, the third-largest in the German state of Baden-Württemberg after Stuttgart and Karlsruhe. Mannheim is among the twenty largest cities in Germany, with a 2012 population of approximately 295,000 inhabitants. The city is at the centre of the larger densely populated Rhine-Neckar Metropolitan Region which has a population of 2,400,000 and is Germany's eighth-largest metropolitan region.