LOPES may refer to:

• LOPES (telescope), a cosmic ray detector array in Karlsruhe, Germany, dismantled in 2013
• LOPES (exoskeleton) (LOwer-extremity Powered ExoSkeleton) a project with the goal to design and implement a gait rehabilitation robot for treadmill training, for people who have suffered a stroke and have impaired motor control

Lopes is a surname of Portuguese origin. It was originally a Patronymic, meaning Son of Lopo, itself being derived from Latin lupus, meaning wolf. Its Spanish equivalent is López, its Italian equivalent is Lupo, its French equivalent is Loup, and its Romanian equivalent is Lupu or Lupescu.

Lopës is a former municipality in the Gjirokastër County, southern Albania. At the 2015 local government reform it became a subdivision of the municipality Tepelenë. The population at the 2011 census was 723. The municipal unit consists of the villages Sinanaj, Matohasanaj, Dorëz, Dhëmblan and Lab Martalloz.