Impermanence is one of the essential doctrines or three marks of existence in Buddhism. The term expresses the Buddhist notion that all of conditioned existence, without exception, is transient, or in a constant state of flux. The mutability of life, that time passes on no matter what happens, is an important aspect of impermanence. The Pali word anicca literally means "inconstant", and arises from a synthesis of two separate words, 'Nicca' and the "privative particle" 'a'. Where the word 'Nicca' refers to the concept of continuity and permanence, 'Anicca' refers to its exact opposite; the absence of permanence and continuity.