Interstate 376 (I-376) is a major auxiliary route of the Interstate Highway System in the U.S. state of Pennsylvania, located within the Allegheny Plateau. It runs from I-80 near Sharon south and east to a junction with the Pennsylvania Turnpike (I-76, its parent) in Monroeville, after having crossed the Turnpike at an interchange earlier in its route. The route serves Pittsburgh, Pennsylvania and its surrounding areas, and is the main access road to Greater Pittsburgh International Airport (PIT). Within Allegheny County, the route runs along the majority of the Penn-Lincoln Parkway, known locally as the Parkway West and the Parkway East. The route is also known by several other names in various jurisdictions. It is currently the fifth-longest auxiliary Interstate route in the system, and second only to I-476 within Pennsylvania.

Interstate 376 (I-376) is a major auxiliary route of the Interstate Highway System in the U.S. state of Pennsylvania, located within the Allegheny Plateau. It runs from I-80 near Sharon south and east to a junction with the Pennsylvania Turnpike (I-76, its parent) in Monroeville, after having crossed the Turnpike at an interchange earlier in its route. The route serves Pittsburgh, Pennsylvania and its surrounding areas, and is the main access road to Greater Pittsburgh International Airport (PIT). Within Allegheny County, the route runs along the majority of the Penn-Lincoln Parkway, known locally as the Parkway West and the Parkway East. The route is also known by several other names in various jurisdictions. It is currently the fifth-longest auxiliary Interstate route in the system, and second only to I-476 within Pennsylvania.