In
molecular biology and
genetics,
GC-content (or
guanine-cytosine content) is the percentage of
nitrogenous bases on a
DNA molecule that are either
guanine or
cytosine (from a possibility of four different ones, also including
adenine and
thymine). This may refer to a specific fragment of DNA or
RNA, or that of the
whole genome. When it refers to a fragment of the genetic material, it may denote the GC-content of part of a gene (domain), single gene, group of genes (or gene clusters), or even a non-coding region. G (guanine) and C (cytosine) undergo a specific
hydrogen bonding, whereas A (adenine) bonds specifically with T (thymine).
