Folding@home (
FAH or
F@h) is a
distributed computing project for disease research that simulates
protein folding, computational
drug design, and other types of
molecular dynamics. The project uses the
idle processing resources of thousands of
personal computers owned by volunteers who have installed the software on their systems. Its main purpose is to determine the mechanisms of protein folding, which is the process by which
proteins reach their
final three-dimensional structure, and to examine the causes of
protein misfolding. This is of significant academic interest with major implications for
medical research into
Alzheimer's disease,
Huntington's disease, and many forms of
cancer, among other diseases. To a lesser extent, Folding@home also tries to
predict a protein's
final structure and determine how other molecules may
interact with it, which has applications in drug design. Folding@home is developed and operated by the Pande Laboratory at
Stanford University, under the direction of Prof. Vijay Pande, and is shared by various scientific institutions and research laboratories across the world.