Exe may refer to:

• .exe, a file extension
• River Exe
• Exe Estuary
• Exe Island
• Exe (locomotive), a British narrow gauge railway locomotive built in 1897 for the Lynton and Barnstaple Railway

.exe is a common filename extension denoting an executable file (the main execution point of a computer program) for DOS, OpenVMS, Microsoft Windows, Symbian or OS/2. Besides the executable program, many .exe files contain other components called resources, such as bitmap graphics and icons which the executable program may use for its graphical user interface.