Botanica may refer to:

• Botanica (band), an American music rock group
• Botanica (Transformers), a character from Beast Machines
• Botanica (series), a series of puzzle adventure games
• Sectorul Botanica, a sector of Chișinău, Moldova
• Botánica, a Latin-American-Caribbean style shop specializing in articles of folk magic and similar merchandise.

A botánica (often written botanica and less commonly known as a hierbería or botica) is a retail store that sells folk medicine, religious candles and statuary, amulets, and other products regarded as magical or as alternative medicine. They also carry oils, incense, perfumes, scented sprays (many of which are thought to have special properties) and various brand name health care products.