Appalachia ( or ) is a cultural region in the Eastern United States that stretches from the Southern Tier of New York to northern Alabama, Mississippi and Georgia. While the Appalachian Mountains stretch from Belle Isle in Canada to Cheaha Mountain in Alabama, the cultural region of Appalachia typically refers only to the central and southern portions of the range. As of the 2010 census, the region was home to approximately 25 million people, containing the major cities of Pittsburgh, Pennsylvania; Knoxville, Tennessee; Chattanooga, Tennessee; Birmingham, Alabama; and Asheville, North Carolina.