For the Amphictyony, an ancient Greek religious organization, see Amphictyonic League.

Amphictyon (; ), in Greek mythology, was the second son of Deucalion and Pyrrha, although there was also a tradition that he was autochthonous (born from the earth); he is also said to be a son of Hellen son of Deucalion and Pyrrha. Amphictyon was king of Thermopylae and married a daughter of Cranaus of Athens. According to some accounts this daughter was named Atthis, although this conflicts with other accounts which relate that she died young as an unmarried virgin. Amphictyon eventually deposed Cranaus, proclaiming himself king of Athens.