Afairiguana is an extinct genus of lizard known from a nearly complete and articulated skeleton discovered in rocks of the Green River Formation of Wyoming, United States. As of the initial description, the skeleton represents the oldest complete iguanian from the Western Hemisphere, and is the oldest representative of a modern iguanian family: Polychrotidae, the anole family.

Afairiguana is an extinct genus of lizard known from a nearly complete and articulated skeleton discovered in rocks of the Green River Formation of Wyoming, United States. As of the initial description, the skeleton represents the oldest complete iguanian from the Western Hemisphere, and is the oldest representative of a modern iguanian family: Polychrotidae, the anole family.