Acetyl coenzyme A or
acetyl-CoA is an important molecule in
metabolism, used in many
biochemical reactions. Its main function is to convey the
carbon atoms within the
acetyl group to the
citric acid cycle (
Krebs cycle) to be
oxidized for energy production. Structure of
coenzyme A (CoASH or CoA) consists of a ß-mercaptoethylamine group linked to the vitamin
pantothenic acid through an amide linkage. The acetyl group of acetyl-CoA is linked by a "high energy" thioester to the sulfhydryl portion of the ß-mercaptoethylamine. It is this thioester bond that makes acetyl-CoA one of the "high energy" compounds. Hydrolysis of the thioester bond is highly exergonic (-31.5 kJ). Acetyl-CoA is produced during breakdown of carbohydrates through
glycolysis as well as fatty acid oxidation and enters the
citric acid cycle.