January 26 – First Battle of Seattle: Marines from the suppress indigenous uprising in response to Governor Stevens' declaration of a "war of extermination" on Native communities.
March 24 – Taiping Rebellion: Suspecting treachery on the part of East King Yang Xiuqing, Shi Dakai garrisons Anhui and begins his march back to the Heavenly Capital, having defeated a strong Xiang Army detachment.