Ertapenem is a
carbapenem antibiotic marketed by
Merck as
Invanz. It is structurally very similar to
meropenem in that it possesses a 1-ß-methyl group. Other members of the carbapenem group (
imipenem,
doripenem, and
meropenem) are broadly active antibacterials that are used for infections caused by difficult to treat or multidrug-resistant bacteria (such as
ESBL expressing
Klebsiella pneumonia). They have very short serum half-lives and must be administered by intravenous infusion every 6 to 8 hours. Ertapenem differs from other carbapenems in having a somewhat less broad spectrum of activity (not against
Pseudomonas aeruginosa), and in that its extended serum half-life allows it to be administered once every 24 hours.